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Biochim Biophys Acta. 2009 May;1787(5):414-20. doi: 10.1016/j.bbabio.2008.10.005. Epub 2008 Oct 25.

The mitochondrial p53 pathway.

Author information

1
Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA.

Abstract

p53 is one of the most mutated tumor suppressors in human cancers and as such has been intensively studied for a long time. p53 is a major orchestrator of the cellular response to a broad array of stress types by regulating apoptosis, cell cycle arrest, senescence, DNA repair and genetic stability. For a long time it was thought that these functions of p53 solely rely on its function as a transcription factor, and numerous p53 target genes have been identified [1]. In the last 8 years however, a novel transcription-independent proapoptotic function mediated by the cytoplasmic pool of p53 has been revealed. p53 participates directly in the intrinsic apoptosis pathway by interacting with the multidomain members of the Bcl-2 family to induce mitochondrial outer membrane permeabilization. Our review will discuss these studies, focusing on recent advances in the field.

PMID:
19007744
PMCID:
PMC2819081
DOI:
10.1016/j.bbabio.2008.10.005
[Indexed for MEDLINE]
Free PMC Article

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