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Cytogenet Cell Genet. 1991;56(1):23-6.

The Chinese hamster cell mutant V-H4 is homologous to Fanconi anemia (complementation group A).

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Department of Human Genetics, Medical Faculty, Free University, Amsterdam, The Netherlands.


V-H4, a mitomycin C (MMC)-sensitive Chinese hamster cell mutant, is phenotypically very similar to Fanconi anemia (FA) cells. Genetic complementation analysis shows that V-H4 belongs to the same complementation group as FA group A cells. Proliferating hybrid cell lines obtained after fusion of V-H4 with normal or FA group B cells show an increased resistance to MMC. Absence of complementation was noted in V-H4 x FA group A hybrid cell lines. This was shown not to be due to the absence of a specific human chromosome. The V-H4 mutant represents the first rodent mutant that is genotypically similar to FA complementation group A cells.

[Indexed for MEDLINE]

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