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Expert Opin Ther Targets. 2008 Dec;12(12):1477-80. doi: 10.1517/14728220802510740 .

Plasma levels of osteopontin before and 24 h after percutaneous coronary intervention.

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University of Athens, Second University Department of Cardiology, Medical School, Attikon General Hospital, 1 Rimini str., 124 62 Athens, Greece.



Previous studies demonstrated that osteopontin (OPN) was increased after vascular injury, such as atherosclerosis and restenosis following angioplasty. We sought to determine the effects of percutaneous coronary intervention (PCI) on plasma OPN levels compared with coronary arteriography (CA).


Plasma OPN levels were determined in 103 patients who underwent CA or PCI with stent implantation, at baseline and 24 h after the procedure. Patients were divided into three groups; group I: patients without significant coronary artery stenosis, group II: patients with coronary artery disease in whom only CA was performed, group III: patients with coronary artery disease who had PCI and stent implantation.


Plasma OPN levels before the procedure were similar in all three groups. OPN levels 24 h after the procedure were significantly higher only in group III compared with baseline. Among three groups, the OPN levels observed in 24 h were significantly higher in group III compared with group I. Patients in group III had significantly higher OPN values after the procedure, depending on the number of stents implanted (p = 0.03).


The increase in OPN levels after PCI suggests that vascular injury due to PCI is responsible for this phenomenon.

[Indexed for MEDLINE]

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