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Org Lett. 2008 Dec 18;10(24):5505-8. doi: 10.1021/ol8020644.

Marineosins A and B, cytotoxic spiroaminals from a marine-derived actinomycete.

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1
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, USA.

Abstract

Two novel spiroaminals, marineosins A and B (1, 2), containing two pyrrole functionalities, were isolated from cultures of a marine sediment-derived actinomycete related to the genus Streptomyces. The marineosins, which appear to be derived from unknown modifications of prodigiosin-like pigment pathways, showed significant inhibition of human colon carcinoma (HCT-116) in an in vitro assay (IC50 = 0.5 microM for marineosin A) and selective activities in diverse cancer cell types.

PMID:
19007176
PMCID:
PMC2654761
DOI:
10.1021/ol8020644
[Indexed for MEDLINE]
Free PMC Article
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