Abstract
Uric acid (UA) crystals are a potent stimulator of inflammation, but how they activate immune cells is not known. In this issue of Immunity, Ng et al. (2008) provide evidence suggesting that UA activates the Syk kinase via membrane cholesterol.
MeSH terms
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Animals
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Cell Membrane / chemistry
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Cell Membrane / metabolism
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Cholesterol / metabolism
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Dendritic Cells / immunology*
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Dendritic Cells / metabolism
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Fibroblasts / immunology
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Fibroblasts / metabolism
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Inflammation / immunology
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Intracellular Signaling Peptides and Proteins / metabolism*
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Microscopy, Atomic Force
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Protein-Tyrosine Kinases / metabolism*
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Syk Kinase
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Uric Acid / immunology*
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Uric Acid / metabolism*
Substances
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Intracellular Signaling Peptides and Proteins
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Uric Acid
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Cholesterol
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Protein-Tyrosine Kinases
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Syk Kinase