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J Neurosci. 2008 Nov 12;28(46):11778-84. doi: 10.1523/JNEUROSCI.3929-08.2008.

A double TRPtych: six views of transient receptor potential channels in disease and health.

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1
Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA. robert-cornell@uiowa.edu

Abstract

At the 2008 Annual Meeting of the Society for Neuroscience, a Mini-Symposium entitled "Contributions to TRP Channels to Neurological Disease" included talks from six heads of newly established laboratories, each with a unique research focus, model system, and set of experimental tools. Some of the questions addressed in these talks include the following. What is the role of transient receptor potential (TRP) channels in pain perception? How do normally functioning TRP channels contribute to cell death pathways? What are the characteristics of TRPpathies, disease states that result from overactive or underactive TRP channels? How are TRP channels regulated by signal transduction cascades? This review summarizes recent results from those laboratories and provides six perspectives on the subject of TRP channels and disease.

PMID:
19005039
PMCID:
PMC2775540
DOI:
10.1523/JNEUROSCI.3929-08.2008
[Indexed for MEDLINE]
Free PMC Article
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