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Eur J Cancer. 2009 Feb;45(3):420-7. doi: 10.1016/j.ejca.2008.09.020. Epub 2008 Nov 12.

Epidemiology of leukaemia and lymphoma in children and young adults from the north of England, 1990-2002.

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1
University of Leeds, Paediatric Epidemiology Group, Centre for Epidemiology and Biostatistics, Worsley Building, Clarendon Way, Leeds LS2 9JT, UK. r.g.feltbower@leeds.ac.uk

Abstract

AIM:

We aimed to describe and contrast the epidemiology of haematological malignancies among 0-14 and 15-24-year-olds in northern England from 1990 to 2002 and compare clinical trial entry by age group.

PATIENTS AND METHODS:

Incidence rates were examined by age, sex and period of diagnosis and differences were tested using Poisson regression. Differences and trends in survival were assessed using Cox regression.

RESULTS:

1680 subjects were included comprising 948 leukaemias and 732 lymphomas. Incidence rates for acute lymphoblastic leukaemia were significantly higher for 0-14 compared to 15-24-year-olds, whilst Hodgkin lymphoma showed the reverse. No significant changes in incidence were observed. 60% of leukaemia patients aged 15-24 years entered trials compared to 92% of 0-14-year-olds. Survival rates were significantly lower and improved less markedly over time for 15-24 compared to 0-14-year-olds, particularly for leukaemia.

CONCLUSIONS:

Trial accrual rates need to be improved amongst 15-24-year-olds and a more structured follow-up approach adopted for this unique population.

PMID:
19004628
DOI:
10.1016/j.ejca.2008.09.020
[Indexed for MEDLINE]
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