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Mol Immunol. 2009 Feb;46(5):761-72. doi: 10.1016/j.molimm.2008.09.026. Epub 2008 Nov 11.

Complement Receptor 1: disease associations and therapeutic implications.

Author information

1
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India.

Abstract

Exaggerated complement activation is a key event in the pathogenesis of a range of autoimmune and inflammatory diseases. Complement Receptor 1 (CR1) has emerged as a molecule of immense interest in gaining insight to the susceptibility, pathophysiology, diagnosis, prognosis and therapy of such diseases. This review brings forth a composite view of the current understanding on the structure, functions, genetics, disease associations and therapeutic implications of CR1.

PMID:
19004497
DOI:
10.1016/j.molimm.2008.09.026
[Indexed for MEDLINE]

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