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Int J Vitam Nutr Res. 2008 May;78(3):121-8. doi: 10.1024/0300-9831.78.3.121.

Protective effect of vitamin C on oxidative stress: a randomized controlled trial.

Author information

1
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. ssasazuk@gan2.res.ncc.go.jp

Abstract

BACKGROUND:

Although a number of reports regarding the role of reactive oxygen species (ROS) as the first step in cancer induction exist, few studies have investigated how vitamin C influences ROS in human plasma.

AIM OF THE STUDY:

Using the ROS assay system, a method recently established by one of the authors, we aimed to evaluate the effect of vitamin C supplementation on serum ROS among subjects diagnosed with chronic gastritis.

METHODS:

A total of 244 Japanese subjects with atrophic gastritis were randomized to take 5-year supplementation of either 50 mg or 500 mg of vitamin C.

RESULTS:

The adjusted difference in the changes of total ROS between baseline and after 5-year supplementation was statistically significant between the intervention groups: 2.70 decrease (corresponds to 1.26% decrease) in the high-dose group and 4.16 increase (corresponds to 3.79% increase) in the low-dose group, p for difference = 0.01.

CONCLUSION:

Vitamin C was suggested to reduce oxidative stress among subjects with atrophic gastritis.

PMID:
19003734
DOI:
10.1024/0300-9831.78.3.121
[Indexed for MEDLINE]
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