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Cogn Neurodyn. 2008 Jun;2(2):115-20. doi: 10.1007/s11571-008-9044-2. Epub 2008 Apr 23.

Cortical network dynamics with time delays reveals functional connectivity in the resting brain.

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Theoretical Neuroscience Group, UMR6152 Institut de Science du Mouvement CNRS, 163 Avenue de Luminy, CP 910, 13288, Marseille Cedex 9, France,


In absence of all goal-directed behavior, a characteristic network of cortical regions involving prefrontal and cingulate cortices consistently shows temporally coherent fluctuations. The origin of these fluctuations is unknown, but has been hypothesized to be of stochastic nature. In the present paper we test the hypothesis that time delays in the network dynamics play a crucial role in the generation of these fluctuations. By tuning the propagation velocity in a network based on primate connectivity, we scale the time delays and demonstrate the emergence of the resting state networks for biophysically realistic parameters.

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