Format

Send to

Choose Destination
Arch Neurol. 2008 Nov;65(11):1518-26. doi: 10.1001/archneur.65.11.1518.

Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci.

Author information

1
Gertrude H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

Abstract

OBJECTIVE:

To identify putative genetic loci related to the risk of late-onset Alzheimer disease (LOAD).

DESIGN:

Linkage analysis and family-based and case-control association analyses from a genomewide scan using approximately 6000 single-nucleotide polymorphic markers at an average intermarker distance of 0.65 cM.

SETTING:

The National Institute on Aging Genetics Initiative for Late-Onset Alzheimer's Disease (NIA-LOAD) was created to expand the resources for studies to identify additional genes contributing to the risk for LOAD.

PARTICIPANTS:

We investigated 1902 individuals from 328 families with LOAD and 236 unrelated control subjects.

MAIN OUTCOME MEASURES:

Clinical diagnosis of LOAD.

RESULTS:

The strongest overall finding was at chromosome 19q13.32, confirming the effect of the apolipoprotein E gene on LOAD risk in the family-based and case-control analyses. However, single-nucleotide polymorphisms at the following loci were also statistically significant in 1 or more of the analyses performed: 7p22.2, 7p21.3, and 16q21 in the linkage analyses; 17q21.31 and 22q11.21 in the family-based association analysis; and 7q31.1 and 22q12.3 in the case-control analysis. Positive associations at 7q31.1 and 20q13.33 were also significant in the meta-analysis results in a publicly available database.

CONCLUSIONS:

Several additional loci may harbor genetic variants associated with LOAD. This data set provides a wealth of phenotypic and genotypic information for use as a resource in discovery and confirmatory research.

PMID:
19001172
PMCID:
PMC2694670
DOI:
10.1001/archneur.65.11.1518
[Indexed for MEDLINE]
Free PMC Article

Publication type, MeSH terms, Substance, Grant support

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center