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Dev Cell. 2008 Nov;15(5):645-55. doi: 10.1016/j.devcel.2008.10.011.

Toward a molecular structure of the eukaryotic kinetochore.

Author information

1
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA. welburn@wi.mit.edu

Abstract

Chromosome segregation in eukaryotes requires a large molecular assembly termed the kinetochore to attach chromosomes to spindle microtubules. Recent work has made substantial progress in defining the composition and activities of the kinetochore, but much remains to be learned about its macromolecular structure. This commentary discusses recent insights into structural features of the kinetochore, how these inform our understanding of its biological function, and the key challenges for the future.

PMID:
19000831
DOI:
10.1016/j.devcel.2008.10.011
[Indexed for MEDLINE]
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