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Photodermatol Photoimmunol Photomed. 2008 Dec;24(6):314-7. doi: 10.1111/j.1600-0781.2008.00383.x.

The perilesional skin in vitiligo: a colorimetric in vivo study of 25 patients.

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  • 1Department of Human and Hereditary Pathology, Institute of Dermatology, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy.



The aim of this work was to study in vivo the perilesional skin in vitiligo with a colorimetric method.


Twenty-five patients affected by vitiligo were included. For each patient, three different areas were considered: the lesional, the perilesional and the normal skin as far as 5 cm from the nearest vitiligo spot. Skin pigmentation measurements were performed with a chromameter.


The results showed that luminance L* decreased significantly in relation to increasing distance from the vitiligo spot. As expected, L* in the vitiligo spot was significantly higher than in the perilesional (P<0.0001) and normal skin (P<0.0001). There was a small difference in L* between normal skin as far as 5 cm from the nearest vitiligo spot and perilesional skin. In contrast, the pigmentation index (b*) gradually increased from lesional to perilesional to normal skin. Furthermore, the comparison of the b* value between the normal skin as far as 5 cm from the nearest vitiligo spot was higher than perilesional skin and it was statistically significant (P<0.0001).


Our results in vivo underline that the perilesional skin near the vitiligo spot is lighter than normal skin as far as 5 cm from the vitiligo spot.

[PubMed - indexed for MEDLINE]
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