Send to

Choose Destination
Phys Rev Lett. 2008 Oct 24;101(17):178103. Epub 2008 Oct 23.

Protein dynamical transition does not require protein structure.

Author information

Physics Department, University at Buffalo, Buffalo, NY 14260, USA.


Terahertz time domain spectroscopy shows that the protein dynamical transition, the rapid increase in protein dynamics occurring at approximately 200 K, needs neither tertiary nor secondary structure. Further, short chain alanine studies find a dynamical transition down to penta-alanine, with no transition observed for di-alanine or tri-alanine. These results reveal the temperature dependence arises strictly from the side-chain interaction with the solvent. The lack of a transition for shorter chain peptides may indicate a qualitative change in this interaction occurs at a specific peptide chain length.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Physical Society
Loading ...
Support Center