Abstract
We demonstrate that enhanced lysozyme resistance of enteropathogenic Escherichia coli requires the plasmid-encoded regulator, Per, and is mediated by factors outside the locus for enterocyte effacement. EspC, a Per-activated serine protease autotransporter protein, conferred enhanced resistance on nonpathogenic E. coli, and a second Per-regulated, espC-independent lysozyme resistance mechanism was identified.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Anti-Bacterial Agents / antagonists & inhibitors*
-
Drug Resistance, Bacterial*
-
Enteropathogenic Escherichia coli / drug effects*
-
Enteropathogenic Escherichia coli / genetics
-
Enteropathogenic Escherichia coli / physiology*
-
Escherichia coli Proteins / metabolism
-
Humans
-
Microbial Sensitivity Tests
-
Microbial Viability
-
Molecular Sequence Data
-
Muramidase / antagonists & inhibitors*
-
Plasmids*
-
Transcription Factors / genetics
-
Transcription Factors / metabolism*
Substances
-
Anti-Bacterial Agents
-
Escherichia coli Proteins
-
EspC protein, E coli
-
Transcription Factors
-
Muramidase