High-throughput multiclass method for antibiotic residue analysis by liquid chromatography-tandem mass spectrometry

J Chromatogr A. 2008 Dec 12;1213(2):189-99. doi: 10.1016/j.chroma.2008.10.023. Epub 2008 Oct 14.

Abstract

A simple and rapid method has been developed for the residue analysis of 39 antibiotics (tetracyclines, quinolones, penicillins, sulfonamides and macrolides) in foodstuffs of animal origin. The method combines an effective extraction technique, which uses water-methanol as extracting solvent, with ultra-high-pressure liquid chromatography-tandem mass spectrometry, allowing both confirmation and quantification in a single chromatographic run. The multiresidue method has been validated in chicken muscle matrix according to European Union Decision 2002/657/EC. It has been implemented as a routine method in a Public Health Laboratory, instead of the five plates test and LC methods previously used.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Animals
  • Anti-Bacterial Agents / analysis*
  • Chickens
  • Chromatography, Liquid / methods*
  • Drug Residues / analysis*
  • Food Contamination / analysis
  • Macrolides / analysis
  • Meat / analysis
  • Muscles / chemistry
  • Penicillins / analysis
  • Quinolones / analysis
  • Spectrometry, Mass, Electrospray Ionization / methods
  • Sulfonamides / analysis
  • Tandem Mass Spectrometry / methods
  • Tetracyclines / analysis

Substances

  • Anti-Bacterial Agents
  • Macrolides
  • Penicillins
  • Quinolones
  • Sulfonamides
  • Tetracyclines