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Pediatr Blood Cancer. 2009 Mar;52(3):396-8. doi: 10.1002/pbc.21807.

Paraneoplastic gastro-intestinal anti-Hu syndrome in neuroblastoma.

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Department of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands.


The anti-Hu syndrome is a well-known paraneoplastic syndrome and may be rarely seen in patients with neuroblastoma. However, it is relatively unknown that anti-Hu antibodies can cause gastro-intestinal signs and symptoms. We report on a child with neuroblastoma who presented with gastro-intestinal disturbances as a result of the anti-Hu syndrome and summaries two similar case reports reported in literature. Neuroblastoma patients with gastro-intestinal disturbances, ranging from constipation to a paralytic ileus, might suffer from the gastro-intestinal anti-Hu syndrome. The causative antibodies can be determined to diagnose or exclude this syndrome, and successful treatment is possible.

[Indexed for MEDLINE]

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