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Science. 2008 Nov 7;322(5903):881-8. doi: 10.1126/science.1156409.

Genetic mapping in human disease.

Author information

1
Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. altshuler@molbio.mgh.harvard.edu

Abstract

Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.

PMID:
18988837
PMCID:
PMC2694957
DOI:
10.1126/science.1156409
[Indexed for MEDLINE]
Free PMC Article

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