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J Cell Physiol. 2009 Mar;218(3):451-4. doi: 10.1002/jcp.21616.

Metastasis and AKT activation.

Author information

1
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. ssheng@med.wayne.edu

Abstract

Metastasis, responsible for 90% of cancer patient deaths, is an inefficient process because many tumor cells die. The survival of metastatic tumor cells should be considered as a critical therapeutic target. This review provides a new perspective regarding the role of AKT in tumor survival, and the rationale to target AKT in anti-metastasis therapies.

PMID:
18988188
DOI:
10.1002/jcp.21616
[Indexed for MEDLINE]

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