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Neuroreport. 2009 Jan 7;20(1):9-12. doi: 10.1097/WNR.0b013e32831b9ce4.

Cocaine does not produce reward in absence of dopamine transporter inhibition.

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1
Department of aPharmacology, Ohio State University College of Medicine, Columbus, Ohio 43210, USA.

Abstract

We have previously reported that knockin mice with a cocaine-insensitive dopamine transporter (DAT-CI mice) do not experience cocaine reward, as measured by conditioned place preference. This conclusion has come under scrutiny because some genetically modified mice show cocaine-induced conditioned place preference in a narrow dose range, that is, responding at doses around 10 mg/kg, but not at 5 and 20 mg/kg, the doses we tested in DAT-CI mice. These results raise the possibility that we have missed the optimal dose for cocaine response. Here we report that cocaine does not produce reward in DAT-CI mice at low, moderate, and high doses, including 10 mg/kg. This study strengthens our conclusion that DAT inhibition is required for cocaine reward in mice with a functional dopaminergic system.

PMID:
18987557
PMCID:
PMC4277863
DOI:
10.1097/WNR.0b013e32831b9ce4
[Indexed for MEDLINE]
Free PMC Article
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