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J Lipid Res. 2009 Apr;50 Suppl:S40-5. doi: 10.1194/jlr.R800062-JLR200. Epub 2008 Nov 5.

5-Lipoxygenase: mechanisms of regulation.

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1
Department Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S-17177 Stockholm, Sweden.

Abstract

5-lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflammation derived from arachidonic acid (AA). LT antagonists are used in treatment of asthma; more recently a potential role also in atherosclerosis has raised considerable interest. Furthermore, possible effects of 5-LO metabolites in relation to tumorigenesis have emerged. Thus, an understanding of the biochemistry of this lipoxygenase has potential implications for treatment of various diseases.

PMID:
18987389
PMCID:
PMC2674731
DOI:
10.1194/jlr.R800062-JLR200
[Indexed for MEDLINE]
Free PMC Article
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