Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 2009 Jan;32(1):56-67. doi: 10.1016/j.tins.2008.09.009. Epub 2008 Nov 3.

The hidden island of addiction: the insula.

Author information

  • 1Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 1032, USA.

Abstract

Most prior research on the neurobiology of addiction has focused on the role of subcortical systems, such as the amygdala, the ventral striatum and mesolimbic dopamine system, in promoting the motivation to seek drugs. Recent evidence indicates that a largely overlooked structure, the insula, plays a crucial part in conscious urges to take drugs. The insula has been highlighted as a region that integrates interoceptive (i.e. bodily) states into conscious feelings and into decision-making processes that involve uncertain risk and reward. Here, we propose a model in which the processing of the interoceptive effects of drug use by the insula contributes to conscious drug urges and to decision-making processes that precipitate relapse.

PMID:
18986715
PMCID:
PMC3698860
DOI:
10.1016/j.tins.2008.09.009
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center