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Am J Obstet Gynecol. 2009 Feb;200(2):160.e1-9. doi: 10.1016/j.ajog.2008.08.049. Epub 2008 Nov 4.

Amniocentesis and mother-to-child human immunodeficiency virus transmission in the Agence Nationale de Recherches sur le SIDA et les Hépatites Virales French Perinatal Cohort.

Collaborators (129)

Tadrist B, Schmit JL, Horlé B, Fournié A, Brault D, Rozan MA, Zakaria A, Sibille G, Pincemaille O, Cayla C, Balde P, Estavoyer JM, Bentata M, Lachassine E, Rodrigues A, Roux D, Douard D, Zenaty D, Brouard J, Elenga N, De Curtis A, Kingue-Ekollo C, Garrait V, Lemerle S, Pichon C, Chambrin V, Labrune P, Clech L, Crenn-Hebert C, Floch-Tudal C, Lagrue A, Reynaud I, Martha S, Ercoli V, Denavit MF, Lahsinat K, Touré K, Devidas A, May A, Granier M, Routier C, Hatchuel Y, Balde P, Jault T, Chalvon Demersay A, Monlouis M, Perré P, Chamouilli JM, Hugon N, Hentgen V, Messaoudi F, Peretti D, Friedman S, Mazingue F, Hammou Y, Subtil D, de Lumley L, Seaume H, Cotte L, Kebaïli K, Doumet A, Cravello L, Thuret I, Karaoui L, Seguy D, Le Lorier B, Talon P, Benos P, Lalande M, Heller-Roussin B, Hubert C, Karoubi P, Reliquet V, Brunet-François C, Poulain P, Berterottiere D, Monpoux F, Bongain A, Deville A, Dendale J, Arsac P, De Gennes C, Matheron S, Batallan A, Lafay Pillet MC, Firtion G, Pannier A, Ciraru-Vigneron N, Rami M, Carlus Moncomble C, Parat S, Blanche S, Rouzioux C, Ayral D, Tubiana R, Dommergues M, Levine M, Faye A, Ottenwalter A, Wallet A, Carbonne B, Aufrant C, Lebrette MG, Dollfus C, Medus M, Bataille H, Rousset MC, Mouchnino G, Munzer M, Brossard V, Allemon MC, Ekoukou D, Khuong MA, Billiemaz K, Bissuel F, Robin M, Segard L, Partisani M, Favreau JJ, Entz-Werle N, Botto C, Hittinger G, Berrebi A, Tricoire J, Besnier JM, Neimann L, Dussaix E, Guillot F, Chacé A.

Author information

1
Assistance Publique-Hôpitaux de Paris (AP-HP), Service de Gynecologie-Obstetrique, Hôpital Louis Mourier, Colombes, and Université Paris 7-Diderot, Paris, France.

Abstract

OBJECTIVE:

The objective of the study was to investigate whether performing an amniocentesis increased mother-to-child transmission of human immunodeficiency virus (HIV)-1 (MTCT).

STUDY DESIGN:

We studied HIV -1 infected mothers and their children enrolled in the multicenter French Perinatal HIV Cohort from 1985 to 2006.

RESULTS:

One hundred sixty-six amniocenteses were performed among 9302 singleton pregnancies, the proportion increasing from 1.0% before 2001 to 4.7% in 2005-2006. Use of highly active antiretroviral therapy (HAART) was more frequent in the amniocentesis group (58.4% vs 33.2%). MTCT tended to be higher in the amniocentesis group, among mothers who received no antiretroviral agents (25.0%; 3/12 vs 16.2%; 343/2113; P = .41) as well as among mothers receiving zidovudine monotherapy or a double-nucleoside reverse transcriptase inhibitor combination (6.1%; 3/49 vs 3.3%; 117/3556; P = .22), but the difference was not significant. Among 81 mothers receiving HAART, there was no case of MTCT.

CONCLUSION:

Our results suggest that amniocentesis is not a major risk factor for mother-to-child transmission in mothers treated with effective antiretroviral therapy.

PMID:
18986640
DOI:
10.1016/j.ajog.2008.08.049
[Indexed for MEDLINE]
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