Abstract
The present paper describes for the first time an intrinsic fluorescent square-planar platinum(II) complex carrying two ursodeoxycholate ligands ([Pt(UDC)2(en)], where UDC(-) = ursodeoxycholate), that emits at room temperature once free in solution. Kinetic studies were carried out in aqueous solution and in the presence of different NaCl concentrations: 4 mM (similar to cytoplasmic concentration) and 150 mM (similar to plasmatic concentration). This novel compound was synthesized from a [PtCl2(en)] complex and shows increased cytotoxic activity against both resting and cycling HeLa cells, with no toxicity for cell lines derived from neoplastic haematopoietic cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Cycle / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects*
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Female
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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Fluorescent Dyes / pharmacology
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HeLa Cells
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Hematologic Neoplasms / metabolism*
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Humans
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Organoplatinum Compounds / chemical synthesis
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Organoplatinum Compounds / chemistry
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Organoplatinum Compounds / pharmacology*
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Ovarian Neoplasms / metabolism*
Substances
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Antineoplastic Agents
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Fluorescent Dyes
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Organoplatinum Compounds
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bisursodeoxycholate(ethylenediamine)platinum(II)