Send to

Choose Destination
See comment in PubMed Commons below
Soc Cogn Affect Neurosci. 2007 Sep;2(3):217-26. doi: 10.1093/scan/nsm014.

Distinct regions of medial rostral prefrontal cortex supporting social and nonsocial functions.

Author information

  • 1Institute of Cognitive Neuroscience, Department of Psychology, University College London, London, UK.


While some recent neuroimaging studies have implicated medial rostral prefrontal cortex (MPFC) in 'mentalizing' and self-reflection, others have implicated this region in attention towards perceptual vs self-generated information. In order to reconcile these seemingly contradictory findings, we used fMRI to investigate MPFC activity related to these two functions in a factorial design. Participants performed two separate tasks, each of which alternated between 'stimulus-oriented phases' (SO), where participants attended to task-relevant perceptual information, and 'stimulus-independent phases' (SI), where participants performed the same tasks in the absence of such information. In half of the blocks ('mentalizing condition'), participants were instructed that they were performing these tasks in collaboration with an experimenter; in other blocks ('non-mentalizing condition'), participants were instructed that the experimenter was not involved. In fact, the tasks were identical in these conditions. Neuroimaging data revealed adjacent but clearly distinct regions of activation within MPFC related to (i) mentalizing vs non-mentalizing conditions (relatively caudal/superior) and (ii) SO vs SI attention (relatively rostral/inferior). These results generalized from one task to the other, suggesting a new axis of functional organization within MPFC.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for PubMed Central
    Loading ...
    Support Center