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Br J Cancer. 2008 Dec 2;99(11):1816-22. doi: 10.1038/sj.bjc.6604764. Epub 2008 Nov 4.

Epstein-Barr virus renders the infected natural killer cell line, NKL resistant to doxorubicin-induced apoptosis.

Author information

1
Department of Hematology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.

Abstract

We established two Epstein-Barr virus (EBV)-infected NKL sublines, which acquired stress resistant phenotype against DNA damage and starvation compared with EBV-negative NKL. EBV-rendered doxorubicin resistance at least partially through NF-kappaB activation and the resultant sustenance of antiapoptotic proteins including Bcl-X(L) and FLIP(L/S).

PMID:
18985034
PMCID:
PMC2600699
DOI:
10.1038/sj.bjc.6604764
[Indexed for MEDLINE]
Free PMC Article

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