Format

Send to

Choose Destination
See comment in PubMed Commons below
Genetics. 2009 Jan;181(1):187-97. doi: 10.1534/genetics.107.080630. Epub 2008 Nov 3.

Population genetic inference from resequencing data.

Author information

1
Department of Oncology, University of Cambridge, Cambridge CB2 0RE, UK.

Erratum in

  • Genetics. 2012 Feb;190(2):829-30.

Abstract

This article is concerned with statistical modeling of shotgun resequencing data and the use of such data for population genetic inference. We model data produced by sequencing-by-synthesis technologies such as the Solexa, 454, and polymerase colony (polony) systems, whose use is becoming increasingly widespread. We show how such data can be used to estimate evolutionary parameters (mutation and recombination rates), despite the fact that the data do not necessarily provide complete or aligned sequence information. We also present two refinements of our methods: one that is more robust to sequencing errors and another that can be used when no reference genome is available.

PMID:
18984575
PMCID:
PMC2621167
DOI:
10.1534/genetics.107.080630
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center