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Clin Liver Dis. 2008 Nov;12(4):861-82, x. doi: 10.1016/j.cld.2008.07.002.

Immune interactions in hepatic fibrosis.

Author information

1
Liver Research Group, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK.

Abstract

Liver cirrhosis is caused by iterative cycles of tissue injury, inflammation, and repair. Although most causes of acute hepatitis resolve without scarring, chronic hepatitis is associated with persistent inflammation and matrix remodeling, which leads to fibrosis and, eventually, cirrhosis. The mechanisms that govern wound healing involve interactions between the innate and adaptive immune systems and stromal cells within a microenvironment composed of cytokines, growth factors, and modified matricellular proteins. The immune system plays a central role in the regulation of fibrosis, tissue repair, and recovery that is vital for the maintenance of tissue homeostasis. Chronic inflammation and fibrosis are inextricably linked and the cellular interactions between immune effector cells, local fibroblasts, and tissue macrophages at sites of scar formation determine the outcome of liver injury and the development of scarring.

PMID:
18984471
PMCID:
PMC2605646
DOI:
10.1016/j.cld.2008.07.002
[Indexed for MEDLINE]
Free PMC Article
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