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Rheum Dis Clin North Am. 2008 Nov;34(4):1025-33, x. doi: 10.1016/j.rdc.2008.08.014.

Therapeutic potential for B-cell modulation in Sjögren's syndrome.

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1
Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Sud 11, Le Kremlin Bicêtre, Institut Pour la Santé et la Recherche Médicale (INSERM) U 802, France. xavier.mariette@bct.aphp-paris.fr

Abstract

B-cell hyperactivity has been recognized for a long time in Sjögren's syndrome. This B-cell activation is firstly polyclonal but can progress to monoclonal B-cell lymphoproliferation. This article addresses the therapeutic potential of B-cell modulation in Sjögren's syndrome.

PMID:
18984420
DOI:
10.1016/j.rdc.2008.08.014
[Indexed for MEDLINE]
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