Send to

Choose Destination
Curr Opin Microbiol. 2008 Dec;11(6):535-40. doi: 10.1016/j.mib.2008.10.004. Epub 2008 Nov 7.

Regulation by destruction: design of the sigmaE envelope stress response.

Author information

Department of Biochemistry and Molecular Biology, 306 S. Frear Laboratory, The Pennsylvania State University, University Park, PA 16802, United States.


The signal transduction pathway governing the sigma(E)-dependent cell envelope stress response in Escherichia coli communicates information from the periplasm to sigma(E) in the cytoplasm via a regulated proteolytic cascade that results in the destruction of the membrane-bound antisigma factor, RseA, and the release of sigma(E) to direct transcription. Regulated proteolysis is used for signal transduction in all domains of life, and these pathways bear remarkable similarities in their architecture and the proteases involved. Work with the pathway governing the sigma(E) response has elucidated key design principles that ensure a rapid yet graded response that is buffered from inappropriate activation. Structural and biochemical studies of the proteases that mediate signal transduction reveal the molecular underpinnings enabling this design.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center