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Arthritis Res Ther. 2008;10(5):225. doi: 10.1186/ar2502. Epub 2008 Oct 17.

Immune regulation of bone loss by Th17 cells.

Author information

1
Department of Immunology, Schering Plough Biopharma, 901 California Avenue, Palo Alto, CA 94304, USA. iannis.adamopoulos@spcorp.com

Abstract

A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.

PMID:
18983698
PMCID:
PMC2592787
DOI:
10.1186/ar2502
[Indexed for MEDLINE]
Free PMC Article

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