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J Proteome Res. 2009 Jan;8(1):72-81. doi: 10.1021/pr800638w.

Temporal proteomic analysis of intestine developing necrotizing enterocolitis following enteral formula feeding to preterm pigs.

Author information

1
Division of Agricultural, Food and Nutritional Science, School of Biological Sciences, The University of Hong Kong, China.

Abstract

Necrotizing enterocolitis (NEC), a serious gastrointestinal inflammatory disease, frequently occurs in preterm neonates that fail to adapt to enteral nutrition. A temporal gel-based proteomics study was performed on porcine intestine with NEC lesions induced by enteral formula feeding. Functional assignment of the differentially expressed proteins revealed that important cellular functions, such as the heat shock response, protein processing; and purine, nitrogen, energy metabolism, were possible involved in the early progression of NEC.

PMID:
18983181
DOI:
10.1021/pr800638w
[Indexed for MEDLINE]

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