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J Clin Invest. 2008 Nov;118(11):3546-56. doi: 10.1172/JCI36130.

The cytokine network in asthma and chronic obstructive pulmonary disease.

Author information

1
National Heart & Lung Institute, Imperial College London, London, UK. p.j.barnes@imperial.ac.uk

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are very common inflammatory diseases of the airways. They both cause airway narrowing and are increasing in incidence throughout the world, imposing enormous burdens on health care. Cytokines play a key role in orchestrating the chronic inflammation and structural changes of the respiratory tract in both asthma and COPD and have become important targets for the development of new therapeutic strategies in these diseases.

PMID:
18982161
PMCID:
PMC2575722
DOI:
10.1172/JCI36130
[Indexed for MEDLINE]
Free PMC Article

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