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J BUON. 2008 Jul-Sep;13(3):353-8.

Radical therapy for muscle-infiltrating bladder cancer (cystectomy or radiotherapy): does age affect the final therapeutic benefit for the patient?

Author information

1
Department of Urology, General Hospital of Ioannina G. Hatzikosta, University Hospital of Ioannina, Ioannina, Greece. dimikalo@gmail.com

Abstract

PURPOSE:

To evaluate the therapeutic outcome of radical cystectomy and radical radiotherapy in patients with T2N0M0 clinical stage bladder cancer in relation to their age.

PATIENTS AND METHODS:

Between 1995-2006, 119 patients with clinical stage T2N0M0 bladder cancer were treated with radical radiotherapy (group A) and were divided in 2 subgroups: >70 years old (A1) and <or=70 years old (A2). Between 1998-2006, 26 patients with the same clinical stage were treated with radical cystectomy (group B) (>70 years old/B1 subgroup and <or=70 years old/B2 subgroup). The following parameters were evaluated in both groups and subgroups: therapeutic outcome (overall survival/OS, local control, development of metastases) and tolerance (side effects and complications of each method). Kaplan-Meier method and log-rank test were used for statistical analyses.

RESULTS:

All group B patients tolerated their treatment very well, without interruptions. The 3-year OS of groups A and B was 39 and 69%, respectively (p=0.032). The 3-year OS of subgroups A1 and A2 was 37.3 and 43.3%, respectively (p=0.085). In the cystectomy group B, 3-year OS of the subgroups was the same (B1: 68.6% and B2: 69.3%; p=0.10). Local control rate for the subgroups A1, A2, B1, B2 was 43, 40, 90 and 84%, respectively. Distant metastatic rate was 14.1, 20, 7.6 and 7.4% for subgroups A1, A2, B1, B2, respectively.

CONCLUSION:

The results of both therapeutic methods in both age groups seem satisfactory. Very good tolerance was also observed. It seems that if a patient is not completely suitable for radical cystectomy or radical radiotherapy age should not be considered as an exclusion factor.

PMID:
18979549
[Indexed for MEDLINE]
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