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Methods Mol Biol. 2008;475:3-20. doi: 10.1007/978-1-59745-250-2_1.

Yeast mating: a model system for studying cell and nuclear fusion.

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  • 1Department of Molecular Biology, Princeton University, Princeton, NJ, USA.


Haploid yeast cells mate to form a zygote, whose progeny are diploid cells. A fundamentally sexual event, related to fertilization, yeast mating nevertheless exhibits cytological properties that appear similar to somatic cell fusion. A large collection of mutations that lead to defects in various stages of mating, including cell fusion, has allowed a detailed dissection of the overall pathway. Recent advances in imaging methods, together with powerful methods of genetic analysis, make yeast mating a superb platform for investigation of cell fusion. An understanding of yeast cell fusion will provide insight into fundamental mechanisms of cell signaling, cell polarization, and membrane fusion.

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