Format

Send to

Choose Destination
See comment in PubMed Commons below
Skull Base. 2008 May;18(3):173-87. doi: 10.1055/s-2007-1003925.

Molecular biology of unreresectable meningiomas: implications for new treatments and review of the literature.

Author information

1
Department of Neurosurgery, University of Virginia Health Sciences Center, Charlottesville, Virginia.

Abstract

Even though meningiomas are most often benign tumors, they can be locally invasive and can develop in locations that prevent surgical treatment. The molecular and biologic factors underlying meningioma development are only now beginning to be understood. Genetic factors such as mutations in the neurofibromatosis-2 gene and in chromosomes 1, 9, and 10 play important roles in meningioma development and may be responsible for atypical tumors in some cases. Cellular factors such as telomerase activation and tyrosine kinase receptor mutations may also play an important role. Finally, autocrine and paracrine factors including epidermal growth factor receptor, platelet-derived growth factor-1, and fibroblast growth factor have been implicated in the development of some tumors. Although the relationship between the various factors implicated in tumor development is unknown, understanding these factors will be critical in the treatment of malignant or surgically inaccessible tumors.

KEYWORDS:

Aggressive; atypical; biology; meningioma; treatment

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Georg Thieme Verlag Stuttgart, New York Icon for PubMed Central
    Loading ...
    Support Center