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Nat Cell Biol. 2008 Nov;10(11):1241-7. doi: 10.1038/ncb1108-1241.

DNA damage and ageing: new-age ideas for an age-old problem.

Author information

1
Department of Genetics, Centre for Biomedical Genetics, Erasmus University Medical Centre.

Abstract

Loss of genome maintenance may causally contribute to ageing, as exemplified by the premature appearance of multiple symptoms of ageing in a growing family of human syndromes and in mice with genetic defects in genome maintenance pathways. Recent evidence revealed a similarity between such prematurely ageing mutants and long-lived mice harbouring mutations in growth signalling pathways. At first sight this seems paradoxical as they represent both extremes of ageing yet show a similar 'survival' response that is capable of delaying age-related pathology and extending lifespan. Understanding the mechanistic basis of this response and its connection with genome maintenance would open exciting possibilities for counteracting cancer or age-related diseases, and for promoting longevity.

PMID:
18978832
PMCID:
PMC4351702
DOI:
10.1038/ncb1108-1241
[Indexed for MEDLINE]
Free PMC Article

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