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Nat Neurosci. 2008 Dec;11(12):1376-7. doi: 10.1038/nn.2219. Epub 2008 Nov 2.

Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli.

Author information

1
Department of Psychology, University of Illinois, Chicago, Illinois 60607, USA. mroitman@uic.edu

Abstract

Rewarding and aversive stimuli evoke very different patterns of behavior and are rapidly discriminated. Here taste stimuli of opposite hedonic valence evoked opposite patterns of dopamine and metabolic activity within milliseconds in the nucleus accumbens. This rapid encoding may serve to guide ongoing behavioral responses and promote plastic changes in underlying circuitry.

PMID:
18978779
PMCID:
PMC3171188
DOI:
10.1038/nn.2219
[Indexed for MEDLINE]
Free PMC Article
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