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J Hepatol. 2009 Jan;50(1):165-73. doi: 10.1016/j.jhep.2008.07.035. Epub 2008 Oct 7.

Comparison of blood tests for liver fibrosis specific or not to NAFLD.

Author information

1
Service d'Hépato-Gastroentérologie, CHU, 49933 Angers Cedex 09, France. paul.cales@univ-angers.fr

Abstract

BACKGROUND/AIMS:

To compare blood tests of liver fibrosis specific for NAFLD: the FibroMeter NAFLD and the NAFLD fibrosis score (NFSA) with a non-specific test, APRI.

METHODS:

Two hundred and thirty-five NAFLD patients with liver Metavir staging and blood markers from two independent centres were randomly assigned to a test (n=121) or a validation population (n=114).

RESULTS:

The highest accuracy--91%--for significant fibrosis was obtained with the FibroMeter whose (i) AUROC (0.943) was significantly higher than those of NFSA (0.884, p=0.008) and APRI (0.866, p<10(-3); p=0.309 vs NFSA) in the whole population, and (ii) misclassification rate (9%) was significantly lower than those of NFSA (14%, p=0.04) and APRI (16%, p=0.002) and did not vary according to centre (14 vs 7%, p=0.07), unlike those of NFSA (25 vs 9%, p=0.001) and APRI (29 vs 11%, p<10(-3)). By using thresholds of 90% predictive values, liver biopsy could have been avoided in most patients: FibroMeter: 97.4% vs NFSA: 86.8% (p<10(-3)) and APRI: 80.0% (p<10(-3)). A new classification provided three reliable diagnosis intervals: F0/1, F0/1/2, F2/3/4 with 91.4% accuracy for FibroMeter, avoiding biopsy in all patients.

CONCLUSIONS:

FibroMeter NAFLD had high performance and provided reliable diagnosis for significant fibrosis, significantly outperforming NFSA and APRI.

PMID:
18977552
DOI:
10.1016/j.jhep.2008.07.035
[Indexed for MEDLINE]

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