Format

Send to

Choose Destination
See comment in PubMed Commons below
Radiother Oncol. 2009 Jan;90(1):99-105. doi: 10.1016/j.radonc.2008.09.028. Epub 2008 Nov 1.

Helical tomotherapy for locoregional irradiation including the internal mammary chain in left-sided breast cancer: dosimetric evaluation.

Author information

1
Department of Radiation Oncology, The Ottawa Hospital Cancer Centre, Ont., Canada. jcaudrelier@ottawahospital.on.ca

Abstract

PURPOSE:

To compare a standard 3- or 4-field technique to intensity modulated radiotherapy with helical tomotherapy (IMRT-HT) in the planning of locoregional breast radiation including the internal mammary chain (IMC).

METHODS AND MATERIALS:

For 10 women with stage III left-sided breast cancer with a planning target volume (PTV) defined by the breast/chest wall and regional nodes, radiotherapy to a dose of 50 Gy in 25 fractions was planned using a standard 3- or 4-field technique and using IMRT-HT. Various metrics were extracted from dose-volume histograms, and were compared using the paired Student's t-test.

RESULTS:

The PTV receiving at least 95% of the prescribed dose did not differ between the two plans, but the VD115% was significantly lower with IMRT-HT. The dose conformality was significantly better with IMRT-HT. The cardiac V30(Gy) was reduced with IMRT-HT. The mean lungs dose was lower with IMRT-HT, as well the V20(Gy). With IMRT-HT, a greater volume of contralateral breast was irradiated to 5 Gy, but a smaller volume of soft tissue received dose above 50 Gy.

CONCLUSIONS:

Compared to a standard technique, IMRT-HT provides similar target coverage, improves dose conformality and dose homogeneity within the PTV, decreases mean lung dose and spares heart, lung and soft tissue from high dose exposure.

PMID:
18977546
DOI:
10.1016/j.radonc.2008.09.028
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center