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Cancer Cell. 2008 Nov 4;14(5):347-9. doi: 10.1016/j.ccr.2008.10.012.

Inflammation joins the "niche".

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1
Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10021, USA.

Abstract

Bone marrow-derived cells have an important role in tumor metastasis and have been reported to "prime" distant tissues for tumor engraftment, although the mechanisms for their recruitment have remained unclear. A new study by Hiratsuka et al. describes an inflammatory signaling pathway that mediates the chemoattraction of myeloid and tumor cells to organ-specific metastatic sites.

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PMID:
18977322
PMCID:
PMC2951628
DOI:
10.1016/j.ccr.2008.10.012
[Indexed for MEDLINE]
Free PMC Article
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