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Trends Parasitol. 2009 Jan;25(1):4-7. doi: 10.1016/ Epub 2008 Oct 30.

Keeping it simple: an easy method for manipulating the expression levels of malaria proteins.

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School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, 3217, Australia.


The ability to genetically manipulate malaria parasites in recent times has contributed considerably to our understanding of the biology of this deadly pathogen. Epp et al. have now expanded the repertoire of molecular tools available for the transgenesis system for the human malaria parasite Plasmodium falciparum by developing a simple methodology to regulate malaria gene expression. In this article, we comment on this technique and discuss its potential applications in the study of the biology of malaria parasites.

[Indexed for MEDLINE]

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