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Fertil Steril. 2009 Sep;92(3):907-12. doi: 10.1016/j.fertnstert.2008.07.1750. Epub 2008 Oct 30.

Comparison of low-dose human menopausal gonadotropin and micronized 17beta-estradiol supplementation in in vitro maturation cycles with thin endometrial lining.

Author information

1
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, McGill Reproductive Center, McGill University Health Center, Montreal, Quebec, Canada. shai.elizur@gmail.com

Abstract

OBJECTIVE:

A challenge of in vitro maturation (IVM) treatment in some women is insufficient development of the endometrium prior to embryo transfer.

DESIGN:

Retrospective study.

SETTING:

McGill Reproductive Center, Montreal, Canada.

PATIENT(S):

Women with endometrial thickness <6 mm on days 6-10 ultrasound (US) scan of IVM treatment.

INTERVENTION(S):

In the human menopausal gonadotropin (hMG) group, 150 IU/day of hMG was started and in the estradiol group, 6 to 12 mg/day of micronized 17beta-estradiol was initiated. Additional US scans were performed 2 to 3 days apart, until endometrial thickness reached > or =8 mm or a dominant follicle (>10 mm) was identified.

MAIN OUTCOME MEASURE(S):

Endometrial lining before oocyte retrival.

RESULT(S):

In both groups endometrial lining significantly thickened following treatment. However, hMG treatment resulted in a higher number of follicles > or =7 mm compared to estradiol (7.4 +/- 4.8 vs. 3.4 +/- 2.5, respectively) and a significantly higher percentage of mature oocytes that were identified on the day of oocyte retrieval (in vivo matured oocytes) (15.1% vs. 10.5%).

CONCLUSION(S):

In IVM designated cycles with a thin endometrium both low-dose hMG and micronized 17beta-estradiol supplementation significantly improve endometrial thickness. However, low-dose hMG results in larger follicles and a greater number of in vivo matured oocytes.

[Indexed for MEDLINE]

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