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Food Chem Toxicol. 2008 Dec;46(12):3842-50. doi: 10.1016/j.fct.2008.10.008. Epub 2008 Oct 14.

Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system.

Author information

1
Radiation and Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, Lab No. 215, New Delhi 110067, India. singh.bimala@gmail.com

Abstract

The chemopreventive effect of different doses of test diet of Foeniculum vulgare Mill (Fennel) seeds was examined on DMBA-induced skin and B(a)P-induced forestomach papillomagenesis in Swiss albino mice. To the best of our knowledge, this is the first report of Fennel seeds exhibiting a significant reduction in the skin and the forestomach tumor incidence and tumor multiplicity as compared to the control group. Further, biochemical assays showed a significant increase in the content/activities of phase I enzymes especially in the case of 6% test diet. A concomitant increase in the activities of the phase II enzymes were observed with all the doses of test diet under study. A significant enhancement in the activities of antioxidant enzymes were observed especially at 4% and 6% test diets of Fennel. Glyoxalase I activity and the content of reduced glutathione were significantly elevated. Expectedly, the levels of peroxidative damage along with lactate dehydrogenase activity, exhibited a significant reduction at all three doses of test diets. These findings were indicative of chemopreventive potential of Fennel against carcinogenesis.

PMID:
18976688
DOI:
10.1016/j.fct.2008.10.008
[Indexed for MEDLINE]

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