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Int J Immunogenet. 2008 Aug;35(4-5):401-3. doi: 10.1111/j.1744-313X.2008.00798.x.

Association of IL-6 gene polymorphism with the outcome of allogeneic haematopoietic stem cell transplantation in Czech patients.

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Department of Immunology, Tissue Typing Laboratory, Palacky University Olomouc, Czech Republic.


Interleukin-6 (IL-6) is an important pro-inflammatory mediator implicated in immune-mediated complications of allogeneic haematopoietic stem cell transplantation (aHSCT). In accord with previous reports, this preliminary study on 56 donor-recipient pairs revealed IL-6-174 single nucleotide polymorphisms as a risk factor for the development of acute graft-versus-host disease and decreased survival after aHSCT.

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