Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Transplant. 2009 Jan;9(1):54-63. doi: 10.1111/j.1600-6143.2008.02458.x. Epub 2008 Oct 31.

Aging augments IL-17 T-cell alloimmune responses.

Author information

1
Department of Internal Medicine, Yale University School of Medicine, Yale University, New Haven, CT, USA.

Abstract

As increasing numbers of elderly patients require solid organ transplantation, the need to better understand how aging modifies alloimmune responses increases. Here, we examined whether aged mice exhibit augmented, donor-specific memory responses prior to transplantation. We found that elevated donor-specific IL-17, but not IFN-gamma, responses were observed in aged mice compared to young mice prior to transplantation. Further characterization of the heightened IL-17 alloimmune response with aging demonstrated that memory CD4(+) T cells were required. Reduced IL-2 alloimmune responses with age contributed to the elevated IL-17 phenotype in vitro, and treatment with an anti-IL-17 antibody delayed the onset of acute allograft rejection. In conclusion, aging leads to augmented, donor-specific IL-17 immune responses that are important for the timing of acute allograft rejection in aged recipients. IL-17 targeting therapies may be useful for averting transplant rejection responses in older transplant recipients.

PMID:
18976294
PMCID:
PMC2626154
DOI:
10.1111/j.1600-6143.2008.02458.x
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center