Format

Send to

Choose Destination
See comment in PubMed Commons below
J Med Chem. 2008 Nov 27;51(22):7045-8. doi: 10.1021/jm801028c.

Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity.

Author information

  • 1The Skaggs Institute for Chemical Biology and the Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. subhash@scripps.edu

Abstract

A systematic analysis using 10 synthetic asimicin stereoisomers revealed that the stereochemistry of the bis-tetrahydrofuran core, including the tetrahydrofuran rings and the adjacent hydroxy functions, had significant effect on its cytotoxicity. Our findings set to rest the highly controversial perception that the stereochemistry of the tetrahydrofuran core has little effect on the activity, which is not true for its cytotoxic effect, and also reinforces the previous conclusion that asimicin is a highly potent anticancer compound.

PMID:
18975929
PMCID:
PMC2670474
DOI:
10.1021/jm801028c
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society Icon for PubMed Central
    Loading ...
    Support Center