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J Am Chem Soc. 2008 Nov 26;130(47):15788-9. doi: 10.1021/ja807156b.

New strategy for quantifying biological zinc by a modified zinpyr fluorescence sensor.

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  • 1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Erratum in

  • J Am Chem Soc. 2009 Jan 14;131(1):396.

Abstract

Substitution of one pyridine by pyrazine in each DPA appendage of ZP1 leads to a new zinc sensor, ZPP1, with a modified background fluorescence and zinc affinity. ZPP1 exhibits a two-step zinc response during fluorescence titrations, which leads to a new method for zinc quantification. The ability of ZPP1 to image and quantify zinc was demonstrated in pancreatic Min6 cells.

PMID:
18975868
PMCID:
PMC2645955
DOI:
10.1021/ja807156b
[PubMed - indexed for MEDLINE]
Free PMC Article
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