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J Bioenerg Biomembr. 2008 Oct;40(5):521-31. doi: 10.1007/s10863-008-9181-7. Epub 2008 Oct 31.

Cytochrome c oxidase: exciting progress and remaining mysteries.

Author information

1
Department of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.

Abstract

Cytochrome c oxidase generates a proton motive force by two separate mechanisms. The first mechanism is similar to that postulated by Peter Mitchell, and is based on electrons and protons used to generate water coming from opposite sides of the membrane. The second mechanism was not initially anticipated, but is now firmly established as a proton pump. A brief review of the current state of our understanding of the proton pump of cytochrome oxidase is presented. We have come a long way since the initial observation of the pump by Mårten Wikström in 1977, but a number of essential questions remain to be answered.

PMID:
18975062
PMCID:
PMC4012550
DOI:
10.1007/s10863-008-9181-7
[Indexed for MEDLINE]
Free PMC Article

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