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Genome Biol. 2008 Oct 30;9(10):R157. doi: 10.1186/gb-2008-9-10-r157.

Boolean implication networks derived from large scale, whole genome microarray datasets.

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  • 1Department of Computer Science, Stanford University, Stanford, CA 94305, USA.

Abstract

We describe a method for extracting Boolean implications (if-then relationships) in very large amounts of gene expression microarray data. A meta-analysis of data from thousands of microarrays for humans, mice, and fruit flies finds millions of implication relationships between genes that would be missed by other methods. These relationships capture gender differences, tissue differences, development, and differentiation. New relationships are discovered that are preserved across all three species.

PMID:
18973690
PMCID:
PMC2760884
DOI:
10.1186/gb-2008-9-10-r157
[PubMed - indexed for MEDLINE]
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